Keywords: elderly, hypertension, HYVET, older adults, treatment In the pilot study, subjects aged over 80 years, with a sustained blood. Kardiol Pol. Jul;66(7); discussion [HYVET study – treatment for hypertension]. [Article in Polish]. Zalewska J(1). Author information. “In the main HYVET study, we aimed to resolve persistent areas of clinical uncertainty about the relative benefits and risks of antihypertensive.

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Association of depression with subsequent mortality, cardiovascular morbidity and incident dementia in people aged 80 and over and suffering from hypertension.

Treatment of hypertension in patients 80 years of age or older. However, with the passage of time, a progressive effort has jyvet made to expand the evidence base for treatment in older adults.

Earlier this year, results from a 1 year open label active studg extension of HYVET were published. Early trials in the field of hypertension focused on adults in their fifties and sixties. There were also significant reductions in rates of other secondary outcomes including fatal stroke, HF, and CV events. Once again, the relative well being of the trial participants limits the potential applicability hyvett these data to the general population.

Published online Aug Trial participants receiving double-blind treatment at their final visit within the main study were deemed eligible for inclusion.

The Hypertension in the Very Elderly Trial – latest data

Again, differences were seen for all-cause mortality 47 deaths; HR 0. All authors have completed the Unified Competing Interest form at http: Introduction The s saw publication of landmark data demonstrating the benefits of anti-hypertensive therapy [ 1 — 3 ].


Br J Clin Pharmacol.

Author information Hybet notes Copyright and License information Disclaimer. HYVET also has a number of methodological issues, namely the protocol amendment which provided for the inclusion of subjects with ISH and the variable methods for measuring blood pressure. Retrieved from ” http: Treating very elderly hypertensive patients is rewarding: National Center for Biotechnology InformationU.

More importantly, the early evidence of mortality benefit resulted in a relatively short duration of follow-up median 1. Whilst these results strengthen the case for early benefit arising from anti-hypertensive therapy in octogenarians, the selective exclusion criteria are questionable. Additional non-protocol—specified antihypertensives were allowed for up to three months, after which patients were given hyvt option of coming off study or entering open follow-up.

Although the model requires further validation, it suggests that cognitive change in those aged over 80 years is small, depends on baseline cognitive function and the relative efficacy of anti-hypertensive treatment [ 25 ].

[HYVET study – treatment for hypertension].

Some have interpreted HYVET as a negative study, since the P value for the primary outcome of stroke did not reach statistical significance. Mortality by race-sex and age. A double-blind placebo-controlled trial with recruitment centres in 13 countries, HYVET prospectively analyzed data from older adults.

Furthermore, standing and seated BPs post-treatment were equivalent, suggesting that antihypertensive therapy was not associated with orthostatic hypotension [ 13 ]. Sociodemographic and lifestyle risk factors for incident dementia and hyvte decline in the HYVET. When analyzing the 90 incident, validated fractures 38 in the active group; 52 in the placebo group and adjusting for baseline risk factors, a HR of 0.


Whilst a statistically hyveet reduction in congestive cardiac failure was also observed unadjusted HR 0.

Given the log linear relationship between systolic blood pressure and clinical outcomes, the mortality and morbidity benefits seen in the trial might be a feature of systolic BP control, particularly in ISH, as opposed to achieved systolic and diastolic blood pressure. Antihypertensive drugs in very old people: Secondary outcomes hyvst rates of fatal stroke, all-cause mortality, and CV events.

HYVET – Wiki Journal Club

Views Read View source View history. Results of the pilot study for the hypertension in the very elderly trial. The optimal target BP among very elderly patients has yet to be defined. This treatment regimen hyvdt also found to be associated with a large and significant reduction in heart failure, whilst proving particularly efficacious in the management of isolated systolic hypertension.

Moreover, active treatment was well tolerated. In fact, serious adverse events SAEs were observed post-randomization in the placebo group.

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